Impaired adenosine-mediated angiogenesis in preeclampsia: potential implications for fetal programming
نویسندگان
چکیده
منابع مشابه
Impaired adenosine-mediated angiogenesis in preeclampsia: potential implications for fetal programming
Preeclampsia is a pregnancy-specific syndrome, defined by such clinical hallmarks as the onset of maternal hypertension and proteinuria after 20 weeks of gestation. The syndrome is also characterized by impaired blood flow through the utero-placental circulation and relative placental ischemia, which in turn, may generate feto-placental endothelial dysfunction. Endothelial dysfunction in offspr...
متن کاملFetal DNA clearance from maternal plasma is impaired in preeclampsia.
BACKGROUND Increased fetal DNA in maternal plasma/serum has been reported in pregnancies complicated by preeclampsia. We hypothesized that impaired clearance of fetal DNA might contribute, at least in part, to the above-mentioned phenomenon. METHODS We studied 7 preeclamptic and 10 control pregnant women. All had male fetuses. Serial blood samples were obtained from before delivery to 6 h pos...
متن کاملImpaired functional capacity of fetal endothelial cells in preeclampsia
OBJECTIVES Preeclampsia is one of the main contributers to maternal and fetal morbidity and mortality during pregnancy. A history of preeclampsia puts mother and offspring at an increased cardiovascular risk in later life. We hypothesized that at the time of birth functional impairments of fetal endothelial cells can be detected in pregnancies complicated by preeclampsia and that a therapeutic ...
متن کاملMaternal-fetal interactions, predictive markers for preeclampsia, and programming.
During pregnancy close interactions between the maternal system and the fetal system via the placenta exist that result in a powerful crosstalk between both individuals. Looking for predictive biomarkers in maternal blood is extremely difficult because of this crosstalk as such markers may be derived from only maternal sources, only placental sources or both. In particular, the concentrations o...
متن کاملFetal Programming: Implications for Beef Cattle Production
The concept of fetal programming, also known as developmental programming, was first hypothesized using human epidemiological data in which environmental stimulus in utero resulted in altered long term development, growth, and disease susceptibility in children from undernourished mothers during the Dutch famine (Barker et al., 1993). Recently, literature regarding the effects of fetal programm...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Frontiers in Pharmacology
سال: 2014
ISSN: 1663-9812
DOI: 10.3389/fphar.2014.00134